Thursday, April 25th 2013 - 21:26 UTC

Uruguay GM lambs which have a luminescence reaction when exposed to UV conditions

Uruguay has a ‘flock’ of nine six-month ‘brilliant’ lambs which behave as any other sheep but are really genetically modified and are planned to help with medicine research. They were born in a farm belonging to the Animal Reproduction Institute of Uruguay (Irauy) a non profit organization connected to the Genetically Modified Animals Unit from the Pasteur Institute, a branch in Montevideo of the renowned French scientific organization.

One of the nine GM ‘luminous’ lambs reacts with green fluorescence

The nine lambs have an incorporated Green fluorescence protein which when exposed to certain ultra-violet conditions the lambs have a luminescence reaction from their skins which makes them easily identifiable as GM.

“Following the development of trans-genesis (generically modified) in animals, science has advanced in the search for alternatives that can be applied to human medicine; for example we already have animals in the world which produce pharmaceutically interesting proteins such as insulin” said Alejo Menchaca the veterinarian founder of Irauy who is head of the research team together with Martina Crispo, who belongs to the Pasteur Institute.

“You chose a gene of certain interest as for example the one responsible for the human growth hormone in humans. You add it to a cow, sheep, goat embryo and the animal incorporates it to its DNA. In the future the calf, lamb or baby-goat is going to produce milk with the growth hormone”, added Menchaca.

Following the milking of the animal, milk is submitted to a complex process by which the protein is isolated and a medicine is elaborated for consumption by humans suffering an endocrinal disease such as shortage or absence of that hormone.

Menchaca then revealed that the world’s best football player Leonel Messi effectively suffered of that disease, and thus he was sent to Spain with only 13 years of age since the Argentine clubs were unable to face such costs.

“Not too far up the road it won’t be necessary for you to be the best player in the world to receive growth hormones” said Menchaca.

Menchaca and Crispo have been working on the project for over two years and are enthusiastic since “there are other examples of high cost medicines that with the milk production of two, three ewes, goats or cows can help human beings overcome specific diseases; potential promises to be revolutionary”.

But the Uruguayan flock of nine GM lambs will not produce insulin or growth hormones in their milk. They are rather more luminous and brilliant: “when exposed to certain ultra-violet conditions the lambs adopt a green fluorescent colour”.

The gene that was incorporated to the ewes’ embryos is responsible for the green fluorescent protein (GFP) in the Aequorea victory jellyfish. Thus almost instantly it is possible to identify the GMs, or not, given their reaction and luminescence of their skin.

“We did not use a protein of medical interest or to help with a particular medicine because we wanted to fine tune the technique. We used the green protein because the colour is easily identifiable in the sheep’s tissues?” underlined Menchaca. He added that this technique which is a kind of ‘bio marker’, making natural processes non invisible, earned the Chemistry Nobel Prize to a US and a Japanese researcher.

“The technique is complex and demands much work and is one of the limiting factors, so despite the global interest and demand it is still a slow process” pointed out Menchaca who anticipated that any further advances ‘could trigger the interest of the pharmaceutical industry”.

“Our focus is generating knowledge, make it public so the scientific community can be informed and help in the long run march to generate tools so humans can live better, but we’re not out in the market to sell technology”.

As to the nine GM lambs they will have a normal sheep’s life closely monitored by researchers.

“They are out in the field as any other sheep, but in better conditions, not the traditional breeding system. They are well looked after, well fed and very much loved”, confessed Menchaca.

But contrary to Dolly the first cloned sheep or Rosita the first Argentine cow which is producing human baby milk, Uruguayan researchers preferred scientific rigour and just give each of them a number.
 

8 comments Feed

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1 rylang23 (#) Apr 26th, 2013 - 12:33 pm Report abuse
Just what we need, and from the “renowned” Pasteur Institute at that (must have become an arm of Monsanto) , is more “Franken-animals”. I am so sorry to see anyone in Uruguay involved with this kind of biological outrage. The benefits from this genetic travesty will pale compared to the blowback that Mother nature will inflict on humanity. Stupid, stupid, stupid.
2 Stevie (#) Apr 26th, 2013 - 05:17 pm Report abuse
Conqueror is thrilled though...
3 ChrisR (#) Apr 27th, 2013 - 04:01 pm Report abuse
@1 @2

You two just cannot grasp anything about science can you, it’s just beyond your comprehension.

The rylang23 character is the one who accused me of being a CIA troll, which I replied by:
”Sep 18, 2010 ... 1 rylang23 (#) Sep 18th, 2010 : I will be moving to Uruguay very soon. And, I am so very proud to hear how President ...

As you have not moved to Uruguay DON’T, WE DON’T WANT YOU. Move to Chubut and be with your windy mate ‘I don’t Think’ because you clearly don’t think either.”

This sort of development paves the way for existing synthetic hormones (which may have problems in some people) to be replaced by naturally produced ones, albeit from a sheep.

Let us say the pair of you in the medium future develop chronic type 1 diabetes and your long term health is severely compromised.

Are you going to refuse this treatment and die at an early stage with bits of your lower limbs being surgically removed just to keep you alive?

NO! I don't believe it, both of you would grasp it with both hands (before you lost those as well).
4 Stevie (#) Apr 27th, 2013 - 05:02 pm Report abuse
Conqueror will for certain grab them with both hands.
That's like night vision without equipment...
5 ChrisR (#) Apr 27th, 2013 - 07:08 pm Report abuse
4 Stevie

But you are forgetting the big (invisible light) UV lamps needed to 'illuminate' the effect.
6 Stevie (#) Apr 27th, 2013 - 08:28 pm Report abuse
You are right, of course...

Conqueror, be patient, we're working on it.
7 rylang23 (#) Apr 30th, 2013 - 03:05 pm Report abuse
BTW ChrisR.....way too late with your request. I've been living in Uruguay for almost a year. Nice place; really like it here. But the expat community....... whew, what a group. Steer clear of that bunch. Oh wait.... that could have been you!
8 ChrisR (#) Apr 30th, 2013 - 09:52 pm Report abuse
7 rylang23

So what are you?

American renegade, Canadian ditto, do tell.

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