Brexit's economic effects will be the focus of a Commons debate later, as government whips work behind the scenes to gain support for Theresa May's deal. Ministers will say it creates a unique partnership with the EU, while Labour argues it will make people poorer.
The Scottish Parliament has voted by 92 to 29 to formally reject the UK government's draft Brexit deal. SNP, Labour, Green and Lib Dem members at Holyrood backed a motion rejecting the proposals, as well as the prospect of leaving without any deal. However, the parties have not come to a consensus on an alternative plan.
Theresa May has suffered three Brexit defeats in the Commons as she set out to sell her EU deal to skeptical MPs. Ministers have agreed to publish the government's full legal advice on the deal after MPs found them in contempt of Parliament for issuing a summary. And MPs backed calls for the Commons to have a direct say in what happens if the PM's deal is rejected next Tuesday.
Brazil's president-elect Jair Bolsonaro said “prudence” was necessary before signing any trade agreement with other nations, in reference to the ongoing negotiations between Mercosur and the European Union.
President Donald Trump on Wednesday indicated he favours imposing import tariffs to protect the US auto industry, which was rocked by this week's announcement of job cuts at General Motors. In two tweets, the president said that extending tariffs already in place for foreign-built small trucks to the car sector would help domestic manufacturers.
The British government is due to publish its economic analysis on the long-term effects of Brexit on the UK. Various scenarios will be set out by the Treasury - with the Daily Telegraph saying it will predict £150bn in lost output over 15 years under no deal, with Theresa May's plan costing £40bn.
Italy's government says it will stick to its high-spending budget plans, setting up a potential stand-off with the European Union over its deficit. PM Giuseppe Conte, who held talks with deputies Matteo Salvini and Luigi Di Maio on Monday, said the objectives for 2019 had already been fixed.
EU leaders have approved an agreement on the UK's withdrawal and future relations - insisting it is the “best and only deal possible”. After 20 months of negotiations, the 27 leaders gave the deal their blessing after less than an hour's discussion.
The government's Brexit deal would leave the UK £100bn a year worse off by 2030, analysis by the National Institute of Economic and Social Research (NIESR) has claimed. The study commissioned by the People's Vote, which wants a second referendum, said GDP would shrink by 3.9% annually.
Theresa May will return to Brussels for Brexit talks this weekend as the UK and EU strive to do a deal in time for Sunday's summit of European leaders. After a two-hour meeting with EU officials, the prime minister said progress was being made on the future shape of EU-UK relations.