The United States and European Union launched negotiations on one of the world's most ambitious free-trade agreements on Monday, promising thousands of jobs and speedier growth on both sides of the Atlantic.
Such a plan was first considered three decades ago but knocked down by France in the 1990s. Europe has now managed to get Paris onside, opening the way to a deal that could boost the EU and US economies by more than 100 billion dollars a year each.
This is a once in a generation prize and we are determined to seize it, said British Prime Minister David Cameron, flanked by US President Barack Obama and the presidents of the European Commission and the European Council at the Group of Eight summit near Enniskillen in Northern Ireland.
The first round of negotiations will take place in Washington on July 8, the White House said in a statement.
The United States and Europe account for almost half of the world's total output and a third of its trade. A free-trade deal therefore holds the prospect of massive economic gains and accompanying jobs.
While both the US and EU negotiators are aware that a final deal will be tough to clinch, they are also conscious of the rising power and influence of China and the need to deepen Western economic integration in order to compete with Asia.
Issues over media protection and cultural exception could still complicate negotiations.
France had threatened to block the start of talks until the EU's other 26 governments accepted its demand to shield movies and online entertainment from competition from Hollywood and Silicon Valley.
Paris eventually won its exception, but Jose Manuel Barroso, the president of the European Commission, said on Monday opposition to a fully comprehensive trade deal was reactionary and part of an anti-globalization agenda.
That sparked a stern response from French President Francois Hollande and other French officials, underlining just how sensitive negotiations over the coming 18 months are set to be.
Obama also warned against narrowing the scope of negotiations.
It is important that we get it right and that means resisting the temptation to downsize our ambitions or avoid tough issues just for the sake of getting a deal, he said.