MercoPress. South Atlantic News Agency

Chemistry Nobel Prize for creators of 'nanoscopy' which peers into molecules of cells

US citizens Eric Betzig and William Moerner and Germany's Stefan Hell won the prize for using fluorescence to take microscopes to a new level

A German and two American scientists won on Wednesday the 2014 Nobel Prize for Chemistry for smashing the size barrier in optical microscopes, allowing researchers to see individual molecules inside living cells.

US citizens Eric Betzig and William Moerner and Germany's Stefan Hell won the prize for using fluorescence to take microscopes to a new level, making it possible to study things like the creation of synapses between brain cells in real time.

“Due to their achievements the optical microscope can now peer into the nanoworld,” the Royal Swedish Academy of Sciences said in awarding the 8 million crown (1.1 million dollar) prize.

Back in 1873, scientists thought there was a limit to what could be seen when Ernst Abbe stipulated that the resolution of an optical microscope could never be better than 0.2 micrometers, or 500 times smaller than the width of a human hair.

But the three Nobel winners bypassed this limit by scanning fluorescent molecules to build up a far more detailed images, leading to the creation of “nanoscopy”, now used widely to peer into the internal molecular machinery of cells.

Modern nanoscale microscopes can follow individual proteins to better understand diseases like Alzheimer's and Parkinson's or to track the development of fertilized eggs as they divide and become embryos.

“This is very, very important to understanding how the cell works and understanding what goes wrong if the cell is diseased,” Hell told a news conference by telephone after learning of the award.

Hell, who is director of the Max Planck Institute for Biophysical Chemistry in Germany, said he was “totally surprised” by the prize, while co-winner Betzig said he was stunned by the news.

“I have been walking around a daze for the last hour, on a nice day in Munich, fearful that my life has changed,” he said from Munich, where he was scheduled to give a lecture.

Betzig works at the Howard Hughes Medical Institute in Ashburn, United States, while Moerner is professor at Stanford University.