Uruguay's future Human Rights Secretary Collette Spinetti will be the first trans woman to hold a position in the South American country's Executive Branch. She is also the third trans woman to reach public office after Michelle Suárez, who became Uruguay's first trans senator in October 2017, and Alejandra da Rosa, who was elected mayor (governor) of Tacuarembó in 2020. All three stemmed from President-elect Yamandú Orsi's Broad Front (Frente Amplio - FA).
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